Infolabmed. Dana bantuan selama lima tahun senilai $ 2,7 juta dari National Institute of Environmental Health Sciences akan membantu para peneliti di University of Illinois di Chicago untuk menjawab pertanyaan mendasar tentang peran arsen dalam pengembangan diabetes dan memeriksa mekanisme dimana selenoprotein - ditemukan di tubuh manusia dalam 25 bentuk yang berbeda - melawan efek arsenik.
Bukti terbaru telah melibatkan polutan lingkungan, termasuk arsenik, dalam pengembangan diabetes, namun sedikit yang diketahui tentang bagaimana arsenik memberikan efek ini.
Arsenik saat ini mencemari sumber air minum yang digunakan oleh lebih dari 100 juta orang di seluruh dunia. Lebih banyak sumber air tanah diperkirakan akan terpengaruh oleh arsenik karena fracking, yang menghasilkan air limbah tercemar arsenik yang dapat meresap ke dalam akuifer bawah tanah, jelas Dr. Robert Sargis, asisten profesor di bidang endokrinologi, diabetes dan metabolisme di UIC College of Medicine dan penyidik utama dan bantuan ini.
Sargis dan rekannya akan menggunakan dana bantuan tersebut untuk memeriksa bagaimana arsenik berperilaku dalam sel beta pankreas - sel yang menghasilkan insulin. Mereka juga akan melihat bagaimana paparan arsenik mempengaruhi tikus yang secara selektif kekurangan selenoprotein dalam sel beta mereka. Dengan menggunakan mikroskop fluoresensi X-ray sinkrotron, mereka akan memetakan lokasi arsenik dan selenium dalam sel beta.
Para peneliti juga akan memeriksa fungsi selenoprotein spesifik yang terlibat dalam peningkatan risiko diabetes - glutathione peroxidase - untuk menentukan bagaimana dampak disfungsi sel beta yang disebabkan arsenik.
Akhirnya, mereka akan memeriksa apakah polimorfisme selenoprotein - perbedaan DNA yang mengkode protein ini - dapat mengubah dampak arsenik pada sel beta dan keseluruhan metabolisme pada tikus. (Sumber : MLO Online / Imad)
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